منابع مشابه
Variability in response to antihypertensive drug treatment.
One of the definitions of the word pragmatic is “practical as opposed to idealistic.” Many of the controversies regarding the issue of the use of race to any degree whatsoever in medical decision-making may be more of a result of tensions between pragmatic and idealistic positions on the issue. The biological determinants of human intraarterial pressure are such that there is no precise cutpoin...
متن کاملDrug metabolism and variability among patients in drug response.
N Engl J Med 2005;352:2211-21. Copyright © 2005 Massachusetts Medical Society. hysicians prescribe drugs on the basis of the characteristics of the medications and on the probability that reliable and reproducible clinical effects will result. However, differences in drug response among patients are common, often leading to challenges in optimizing a dosage regimen for an individual patient. Mo...
متن کاملBioinformatics and variability in drug response: a protein structural perspective.
Marketed drugs frequently perform worse in clinical practice than in the clinical trials on which their approval is based. Many therapeutic compounds are ineffective for a large subpopulation of patients to whom they are prescribed; worse, a significant fraction of patients experience adverse effects more severe than anticipated. The unacceptable risk-benefit profile for many drugs mandates a p...
متن کاملDrug disease interactions: role of inflammatory mediators in depression and variability in antidepressant drug response.
Increased cytokine expression and concurrent psychiatric symptoms were initially observed after administration of cytokines to patients afflicted with cancer, hepatitis and multiple sclerosis. Cytokines are a diverse group of soluble messenger proteins involved in the regulation, repair of cells, and control of immune events. During an inflammatory event expression of CD4+ T-lymphocyte helper (...
متن کاملDrug disease interactions: role of inflammatory mediators in pain and variability in analgesic drug response.
Pain has both physical and emotional components. Physical noxious stimuli activate peripheral sensory neurons that, in turn, relay signals to the spinal and supraspinal nuclei. Subsequently, these signals activate areas within the brain associated with pain. Despite considerable knowledge in this area, analgesics may provide pain complete relief in only one out of five patients. Failure to mana...
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ژورنال
عنوان ژورنال: Journal of Korean Society for Clinical Pharmacology and Therapeutics
سال: 1995
ISSN: 1225-5467
DOI: 10.12793/jkscpt.1995.3.1.91